Which hormone stimulates the secretion of gastric juice from the stomach glands?

Which hormone stimulates the secretion of gastric juice from the stomach glands?

• A. Gastrin
• B. Secretin
• C. Cholecystokinin
• D. Motilin

Answer: (A)

Gastrin is the hormone released by G cells in the stomach that directly drives the gastric glands to secrete gastric juice. It stimulates the parietal cells to produce hydrochloric acid and the chief cells to release pepsinogen, increasing the overall juice produced as soon as food is present. Its release is triggered by the presence of proteins and peptides in the stomach, stomach distension, and vagal stimulation, all of which help prepare the stomach for digestion. The acid environment created by this secretion then supports enzyme activity and protein digestion. The other hormones have different primary roles: secretin mainly boosts bicarbonate-rich secretions from the pancreas and slows acid secretion; cholecystokinin mostly acts on the pancreas and gallbladder and can slow gastric emptying; motilin regulates motility in the small intestine. So gastrin best fits the role of stimulating gastric juice secretion from the stomach glands.

Gastrin is the hormone released by G cells in the stomach that directly drives the gastric glands to secrete gastric juice. It stimulates the parietal cells to produce hydrochloric acid and the chief cells to release pepsinogen, increasing the overall juice produced as soon as food is present. Its release is triggered by the presence of proteins and peptides in the stomach, stomach distension, and vagal stimulation, all of which help prepare the stomach for digestion. The acid environment created by this secretion then supports enzyme activity and protein digestion. The other hormones have different primary roles: secretin mainly boosts bicarbonate-rich secretions from the pancreas and slows acid secretion; cholecystokinin mostly acts on the pancreas and gallbladder and can slow gastric emptying; motilin regulates motility in the small intestine. So gastrin best fits the role of stimulating gastric juice secretion from the stomach glands.